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What Causes Headaches and When Should You Worry?

Headache is one of the most common medical complaints worldwide — nearly everyone experiences headaches, and they account for millions of physician visits annually. The vast majority of headaches are...

DM

Dr. Michael Lee

Neurologist

|
4 min read
|April 30, 2026
Medically reviewed by Dr. Michael Lee · Editorial Policy

Headache is one of the most common medical complaints worldwide — nearly everyone experiences headaches, and they account for millions of physician visits annually. The vast majority of headaches are benign and self-limited. But a small subset signal serious underlying pathology that requires urgent evaluation. Knowing the difference — and knowing which features of a headache should prompt emergency care — is essential knowledge.

The Anatomy Of Headache Pain

The brain itself has no pain receptors (nociceptors). Headache pain originates from pain-sensitive structures surrounding the brain: blood vessel walls (including meningeal arteries and the dural sinuses), the meninges (the membranes surrounding the brain — particularly the pain-sensitive dura), scalp muscles and fascia, the periosteum of the skull, cranial nerves (particularly the trigeminal nerve, cranial nerve V, which is the primary pain nerve for the head), and the upper cervical nerve roots.

Categories: Primary Vs. Secondary Headaches

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Medical Disclaimer: This article is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of your physician or other qualified health provider with any questions you may have regarding a medical condition.

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Sources & References

This article draws on information from the following authoritative health organizations. Always consult a qualified healthcare professional for personal medical advice.

  1. 1NIH National Institute of Neurological Disorders and Stroke
  2. 2American Migraine Foundation
  3. 3Mayo Clinic: Headaches
  4. 4Cleveland Clinic: Headache types and treatment
  5. 5Harvard Health: Headache causes and treatment
  6. 6American Academy of Neurology: Headache guidelines